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Tuesday, October 25, 2016

Gleevec

Pronunciation: i-MA-tin-ib
Generic Name: Imatinib
Brand Name: Gleevec

Gleevec is used for:

Treating certain types of leukemia, certain bone marrow diseases, a certain type of skin cancer, and certain intestinal tumors (eg, gastrointestinal stromal tumors [GIST]). It may also be used to prevent cancer from growing in patients after surgical removal of GIST. It is also used to treat mastocytosis (a buildup of large amounts of mast cells in certain parts of the body) or hypereosinophilic syndrome (a buildup of large amounts of eosinophils in the body). It may also be used for other conditions as determined by your doctor.

Gleevec is a protein-tyrosine kinase inhibitor. It works by preventing the growth of cancer cells.

Do NOT use Gleevec if:

you are allergic to any ingredient in Gleevec

you take warfarin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Gleevec:

Some medical conditions may interact with Gleevec. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have liver or kidney problems, lung problems, or heart problems (eg, heart failure), or if you are at risk of heart failure

if you have had your thyroid gland removed

if you have bone marrow problems, low white blood cell levels, or low blood platelet levels

if you have a history of swelling (edema) or fluid retention

if you are or will be taking an iron supplement

if you are receiving chemotherapy

Some MEDICINES MAY INTERACT with Gleevec. Tell your health care provider if you are taking any other medicines, especially any of the following:

Warfarin because side effects, including the risk of bleeding, may be increased

Azole antifungals (eg, itraconazole, ketoconazole), ketolide antibiotics (eg, telithromycin), macrolide antibiotics (eg, clarithromycin, erythromycin), nefazodone, or protease inhibitors (eg, ritonavir) because they may increase the risk of Gleevec's side effects

Barbiturates (eg, phenobarbital), carbamazepine, dexamethasone, hydantoins (eg, phenytoin), oxcarbazepine, primidone, rifamycins (eg, rifampin), or St. John's wort because they may decrease Gleevec's effectiveness

Acetaminophen, alfentanil, benzodiazepines (eg, alprazolam), calcium channel blockers (eg, nifedipine), cyclosporine, ergot derivatives (eg, ergotamine), fentanyl, HMG-CoA reductase inhibitors (eg, simvastatin), pimozide, quinidine, sirolimus, or tacrolimus because the risk of their side effects may be increased by Gleevec

Levothyroxine because its effectiveness may be decreased by Gleevec

This may not be a complete list of all interactions that may occur. Ask your health care provider if Gleevec may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Gleevec:

Use Gleevec as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Gleevec by mouth with a meal and a full glass of water (8 oz/240 mL).

If you have trouble swallowing tablets whole, talk with your doctor or pharmacist. You may dissolve your dose in a glass of water or apple juice. The amount of liquid will vary depending on your dose. Ask your doctor or pharmacist for instructions. Stir the mixture well and drink immediately.

Do not eat grapefruit or drink grapefruit juice while you take Gleevec.

Take Gleevec on a regular schedule to get the most benefit from it. Taking Gleevec at the same time each day will help you to remember to take it.

If you miss a dose of Gleevec, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Gleevec.

Important safety information:

Gleevec may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Gleevec with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Do NOT take more than the recommended dose or take for longer than prescribed without checking with your doctor.

Tell your doctor or dentist that you take Gleevec before you receive any medical or dental care, emergency care, or surgery.

Gleevec may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.

Gleevec may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.

Do not receive a live vaccine (eg, measles, mumps) while you are taking Gleevec. Talk with your doctor before you receive any vaccine.

Check your weight every morning and keep a log. Report any 3- to 5-pound weight gain to your doctor.

Gleevec may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Gleevec. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.

A serious and possibly fatal condition called tumor lysis syndrome (TLS) has been reported in certain patients taking Gleevec. Contact your doctor right away if you develop symptoms such as fast or irregular heartbeat; fainting; decreased urination; muscle weakness or cramps; nausea, vomiting, diarrhea, or loss of appetite; or sluggishness. Discuss any questions or concerns with your doctor.

If you may become pregnant, you must use an effective form of birth control while you take Gleevec. If you have questions about effective birth control, talk with your doctor.

Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you take Gleevec. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Gleevec with caution in the ELDERLY; they may be more sensitive to its effects, especially swelling and fluid retention.

Gleevec may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they take Gleevec.

Gleevec should be used with extreme caution in CHILDREN younger than 2 years; safety and effectiveness in these children have not been confirmed.

PREGNANCY and BREAST-FEEDING: Gleevec may cause harm to the fetus. Do not become pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. You will need to discuss the benefits and risks of taking Gleevec while you are pregnant. Gleevec is found in breast milk. Do not breast-feed while taking Gleevec.

Possible side effects of Gleevec:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; constipation; cough; diarrhea; dizziness; gas; hair loss; headache; increased tear production; joint pain; loss of appetite; mild muscle cramps or pain; mild stomach pain; nausea; night sweats; nose and throat irritation; stomach cramps or upset; stuffy or runny nose; taste changes; tiredness; trouble sleeping; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, bloody, or tarry stools; bone pain; change in the amount of urine produced; chest pain; chills, fever, or sore throat; confusion; dark urine; depression; fast or irregular heartbeat; mouth pain, sores, or swelling; muscle pain, weakness, or cramping; one-sided weakness; pale stools; red, swollen, blistered, or peeling skin; severe or persistent headache; severe or persistent stomach pain; severe tiredness or weakness; shortness of breath; slurred speech; sudden, unusual weight gain; swelling of the hands, feet, ankles, or around the eyes; trouble swallowing or talking; unusual bruising or bleeding; vision problems; vomit that looks like coffee grounds; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Gleevec side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; fever; headache; loss of appetite; muscle pain or spasms; nausea; stomach pain; swelling; unusual bruising or bleeding; unusual tiredness or weakness; vomiting.

Proper storage of Gleevec:

Store Gleevec at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Gleevec out of the reach of children and away from pets.

General information:

If you have any questions about Gleevec, please talk with your doctor, pharmacist, or other health care provider.

Gleevec is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Gleevec. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Gleevec resources

Gleevec Side Effects (in more detail)
Gleevec Use in Pregnancy & Breastfeeding
Drug Images
Gleevec Drug Interactions
Gleevec Support Group
12 Reviews for Gleevec - Add your own review/rating

Gleevec Prescribing Information (FDA)

Gleevec Consumer Overview

Gleevec Monograph (AHFS DI)

Gleevec Advanced Consumer (Micromedex) - Includes Dosage Information

Imatinib Professional Patient Advice (Wolters Kluwer)

Compare Gleevec with other medications

Acute Lymphoblastic Leukemia
Chronic Eosinophilic Leukemia
Chronic Myelogenous Leukemia
Dermatofibrosarcoma Protuberans
Gastrointestinal Stromal Tumor
Hypereosinophilic Syndrome
Myelodysplastic Diseases
Myeloproliferative Disorders
Systemic Mastocytosis

Care One Acid Reducer Plus Antacid

Dosage Form: tablet, chewable
American Sales Company Acid Reducer + Antacid Drug Facts

Active ingredient (in each chewable tablet)

Famotidine 10 mg

Calcium carbonate 800 mg

Magnesium hydroxide 165 mg

Purpose

Acid reducer

Antacid

Uses

relieves heartburn associated with acid indigestion and sour stomach

Warnings

Allergy alert: Do not use if you are allergic to famotidine or other acid reducers

Do not use

if you have trouble or pain swallowing food, vomiting with blood, or bloody or black stools. These may be signs of a serious condition. See your doctor.

with other acid reducers

Ask a doctor before use if you have

had heartburn over 3 months. This may be a sign of a more serious condition.

heartburn with lightheadedness, sweating, or dizziness

chest pain or shoulder pain with shortness of breath; sweating; pain spreading to arms, neck or shoulders; or lightheadedness

frequent chest pain

frequent wheezing, particularly with heartburn

unexplained weight loss

nausea or vomiting

stomach pain

Ask a doctor or pharmacist before use if you are

presently taking a prescription drug. Antacids may interact with certain prescription drugs.

Stop use and ask a doctor if

your heartburn continues or worsens

you need to take this product for more than 14 days

If pregnant or breast-feeding,

ask a health professional before use.

Keep out of reach of children.

In case of overdose, get medical help or contact a Poison Control Center right away.

Directions

adults and children 12 years and over:

do not swallow tablet whole: chew completely

to relieve symptoms, chew 1 tablet before swallowing

do not use more than 2 chewable tablets in 24 hours

children under 12 years: ask a doctor

Other information

each tablet contains: calcium 320 mg; magnesium 65 mg

Phenylketonurics: Contains Phenylalanine 2.2 mg per tablet

read the directions and warnings before use

read the bottle label. It contains important information.

store at 20°-25°C (68°-77°F)

protect from moisture

Inactive ingredients

aspartame, D&C red no. 7 calcium, dextrates, FD&C blue no. 1 lake, FD&C red no. 40 lake, flavor, glyceryl monostearate, lactose anhydrous, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyacrylate dispersion, polysorbate 80, povidone, pregelatinized starch, sodium starch glycolate, talc

Questions or comments?

1-800-719-9260

Principal Display Panel

Compare to the Active Ingredients in Pepcid® Complete

Famotidine 10 mg/Calcium Carbonate 800 mg/Magnesium Hydroxide 165 mg Tablets/Chewable

Acid Reducer + Antacid

Dual Action

Just One Tablet Relieves Heartburn Due to Acid Indigestion

Berry Flavor

Acid Reducer + Antacid Label

Care One Acid Reducer Plus Antacid DUAL ACTION
famotidine, calcium carbonate,magnesium hydroxide tablet, chewable

Product Information
Product Type	HUMAN OTC DRUG	NDC Product Code (Source)	41520-321
Route of Administration	ORAL	DEA Schedule

Active Ingredient/Active Moiety
Ingredient Name	Basis of Strength	Strength
FAMOTIDINE (FAMOTIDINE)	FAMOTIDINE	10 mg
MAGNESIUM HYDROXIDE (MAGNESIUM HYDROXIDE)	MAGNESIUM HYDROXIDE	165 mg
CALCIUM CARBONATE (CARBONATE ION)	CALCIUM CARBONATE	800 mg

Inactive Ingredients
Ingredient Name	Strength
No Inactive Ingredients Found

Product Characteristics
Color	PINK (mottled)	Score	no score
Shape	ROUND (bi-layered)	Size	17mm
Flavor	BERRY	Imprint Code	L321
Contains

Packaging
#	NDC	Package Description	Multilevel Packaging
1	41520-321-63	25 TABLET In 1 BOTTLE	None
2	41520-321-65	30 TABLET In 1 BOTTLE	None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
ANDA	ANDA077355	08/01/2008

Labeler - American Sales Company (809183973)

Revised: 05/2009American Sales Company

More Care One Acid Reducer Plus Antacid resources

Care One Acid Reducer Plus Antacid Use in Pregnancy & Breastfeeding
Care One Acid Reducer Plus Antacid Drug Interactions
Care One Acid Reducer Plus Antacid Support Group
0 Reviews for Care One Acid Reducer Plus Antacid - Add your own review/rating

Compare Care One Acid Reducer Plus Antacid with other medications

GERD

Sandoz Bupropion

Sandoz Bupropion may be available in the countries listed below.

Ingredient matches for Sandoz Bupropion

Bupropion

Bupropion hydrochloride (a derivative of Bupropion) is reported as an ingredient of Sandoz Bupropion in the following countries:

Canada

International Drug Name Search

ginseng

Generic Name: ginseng (GIN seng)

Brand Names:

What is ginseng?

The use of ginseng in cultural and traditional settings may differ from concepts accepted by current Western medicine. When considering the use of herbal supplements, consultation with a primary health care professional is advisable. Additionally, consultation with a practitioner trained in the uses of herbal/health supplements may be beneficial, and coordination of treatment among all health care providers involved may be advantageous.

A number of ginseng species used in herbal products grow around the world. Some of these plants include American ginseng, Korean ginseng, Sanchi ginseng, Chikusetsu ginseng, Himalayan ginseng, zhuzishen, and dwarf ginseng. Ginseng is also known as Siberian ginseng, devil's shrub, eleuthero, touch-me-not, and wild pepper.

Ginseng has been used to improve the body's resistance to stress and to increase vitality.

Ginseng has not been evaluated by the FDA for safety, effectiveness, or purity. All potential risks and/or advantages of ginseng wort may not be known. Additionally, there are no regulated manufacturing standards in place for these compounds. There have been instances where herbal/health supplements have been sold which were contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Ginseng may also have uses other than those listed in this product guide.

What is the most important information I should know about ginseng?

Do not take ginseng without first talking to your doctor if you have a bleeding or blood clotting disorder, diabetes, high blood pressure or heart disease, or if you are taking any medicines to prevent or treat these conditions.

Ginseng has not been evaluated by the FDA for safety, effectiveness, or purity. All potential risks and/or advantages of ginseng may not be known. Additionally, there are no regulated manufacturing standards in place for these compounds. There have been instances where herbal/health supplements have been sold which were contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

What should I discuss with my health care provider before taking ginseng?

Talk to your doctor before taking ginseng if you have any other medical conditions, allergies (especially to plants), or if you take other medicines or herbal/health supplements. Ginseng may not be recommended in some situations.

Do not take ginseng without first talking to your doctor if you are pregnant or could become pregnant. It is not known whether ginseng will harm an unborn baby. Do not take ginseng without first talking to your doctor if you are breast-feeding a baby. It is also not known whether ginseng will harm a nursing infant. There is no information available regarding the use of ginseng by children. Do not give any herbal/health supplement to a child without first talking to the child's doctor.

How should I take ginseng?

If you choose to take ginseng, use it as directed on the package or as directed by your doctor, pharmacist, or other health care provider.

Standardized extracts, tinctures, and solid formulations of herbal/health supplements may provide a more reliable dose of the product.

Ginseng is available in various formulations

Do not use different formulations (e.g., tablets, topical formulations, teas, tinctures, and others) of ginseng at the same time, unless specifically directed to do so by a health care professional. Using different formulations together increases the risk of an overdose of ginseng.

Store Ginseng as directed on the package. In general, ginseng should be protected from light and moisture.

What happens if I miss a dose?

Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra ginseng to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

A massive ginseng overdose has been reported to cause the "Ginseng Abuse Syndrome" which is characterized by sleeplessness, muscle tension, and swelling or fluid retention.

What should I avoid while taking ginseng?

Follow your healthcare provider's instructions about any restrictions on food, beverages, or activity.

Ginseng side effects

Although uncommon, allergic reactions to ginseng have been reported. Stop taking ginseng and seek emergency medical attention if you experience symptoms of a serious allergic reaction including difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ginseng?

Do not take ginseng without first talking to your doctor if you are taking any of the following medicines:

any heart or blood pressure medicines;

a medicine to control blood sugar levels such as insulin, glipizide (Glucotrol), glyburide (Glynase, Diabeta, Micronase), chlorpropamide (Diabinese), tolbutamide (Orinase), tolazamide (Tolinase), troglitazone (Rezulin), rosiglitazone (Avandia), repaglinide (Prandin), metformin (Glucophage), and others;

warfarin (Coumadin);

aspirin;

a nonsteroidal anti-inflammatory drug (NSAID) including ibuprofen (Advil, Motrin, Nuprin, others), naproxen (Aleve, Naprosyn, Naprelan, Anaprox, others), ketoprofen (Orudis KT, Orudis), indomethacin (Indocin), etodolac (Lodine), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), tolmetin (Tolectin), and others;

ardeparin (Normiflo);

dalteparin (Fragmin);

danaparoid (Orgaran);

enoxaparin (Lovenox); or

heparin.

You may not be able to take ginseng, or you may require a dosage adjustment or special monitoring while taking ginseng if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with ginseng or affect your condition. Talk to your doctor, pharmacist, or health care provider before taking any prescription or over-the-counter medicines or other herbal/health supplements.

More ginseng resources

Ginseng Side Effects (in more detail)
Ginseng Use in Pregnancy & Breastfeeding
Ginseng Drug Interactions
Ginseng Support Group
0 Reviews for Ginseng - Add your own review/rating

Ginseng Natural MedFacts for Professionals (Wolters Kluwer)

Ginseng Natural MedFacts for Consumers (Wolters Kluwer)

Ginseng MedFacts Consumer Leaflet (Wolters Kluwer)

Compare ginseng with other medications

Herbal Supplementation

Where can I get more information?

Consult with a licensed healthcare professional before using any herbal/health supplement. Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments.

See also: ginseng side effects (in more detail)

glimepiride

Generic Name: glimepiride (glye MEP ir ide)

Brand Names: Amaryl

What is glimepiride?

Glimepiride is an oral diabetes medicine that helps control blood sugar levels. This medication helps your body respond better to insulin produced by your pancreas.

Glimepiride is used together with diet and exercise to treat type 2 diabetes. Insulin or other diabetes medicines are sometimes used in combination with glimepiride if needed.

Glimepiride may also be used for purposes not listed in this medication guide.

What is the most important information I should know about glimepiride?

Do not use this medication if you are allergic to glimepiride, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Before taking glimepiride, tell your doctor if you are allergic to sulfa drugs, or if you have heart disease, liver disease, kidney disease, an enzyme deficiency (G6PD), adrenal or pituitary gland problems, or if you are under-nourished.

Take care not to let your blood sugar get too low. Low blood sugar (hypoglycemia) can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency.

Glimepiride is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

What should I discuss with my doctor before taking glimepiride?

You should not use this medication if you are allergic to glimepiride or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

To make sure you can safely take glimepiride, tell your doctor if you have any of these other conditions:

heart disease;

liver or kidney disease;

an allergy to sulfa drugs;

an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);

adrenal or pituitary gland problems; or

if you are under-nourished.

FDA pregnancy category C. It is not known whether glimepiride will harm an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether glimepiride passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take glimepiride?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Glimepiride is usually taken once a day with breakfast or the first main meal of the day. Follow your doctor's instructions. Take glimepiride with a full glass of water. Know the signs of low blood sugar (hypoglycemia) and how to recognize them: headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating.

Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.

Your dose needs may change if you are ill, if you have a fever or infection, or if you have surgery or a medical emergency.

Ask your doctor how to adjust your glimepiride dose if needed. Do not change your medication dose or schedule without your doctor's advice.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Visit your doctor regularly.

Glimepiride is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

Store at room temperature away from moisture and heat.

See also: Glimepiride dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Use glimepiride regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A glimepiride overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, confusion, tremors, sweating, trouble speaking, blurred vision, nausea, fainting, and seizure (convulsions).

What should I avoid while taking glimepiride?

Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment. Avoid exposure to sunlight or tanning beds. Glimepiride can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Glimepiride side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

severe skin rash, itching, redness, or irritation;

pale skin, easy bruising or bleeding, fever, unusual weakness;

numbness or tingly feeling;

trouble breathing;

feeling like you might pass out;

dark urine, clay-colored stools;

upper stomach pain, low fever, jaundice (yellowing of the skin or eyes); or

nausea, vomiting, loss of appetite, feeling restless or irritable, confusion, hallucinations, muscle pain or weakness, and/or seizure.

Less serious side effects may include:

dizziness, headache, tired feeling;

mild nausea, vomiting, stomach pain, diarrhea;

increased skin sensitivity to sunlight; or

mild itching or skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Glimepiride Dosing Information

Usual Adult Dose for Diabetes Mellitus Type II:

Initial dose: 1 to 2 mg orally once a day.
Maintenance dose: 1 to 4 mg orally once a day.
Glimepiride should be administered with breakfast or the first main meal. Maximum recommended dose is 8 mg per day.

Usual Geriatric Dose for Diabetes Mellitus Type II:

Initial dose: 1 mg orally once a day.
Maintenance dose: 1 to 4 mg orally once a day.

Usual Pediatric Dose for Diabetes Mellitus Type II:

>8 years:
Initial dose: 1 to 2 mg orally once a day.
Maintenance dose: 1 to 4 mg orally once a day.
Glimepiride should be administered with breakfast or the first main meal. Maximum recommended dose is 8 mg per day.

What other drugs will affect glimepiride?

Using certain medicines can make it harder for you to tell when you have low blood sugar. Tell your doctor if you use any of the following:

albuterol (Proventil, Ventolin);

clonidine (Catapres);

reserpine;

a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others.

You may be more likely to have hypoglycemia (low blood sugar) if you take glimepiride with:

clarithromycin (Biaxin);

disopyramide (Norpace);

exenatide (Byetta);

fluoxetine (Prozac, Sarafem);

probenecid (Benemid);

an antibiotic such as ciprofloxacin (Cipro), ofloxacin (Floxin), norfloxacin (Noroxin), levofloxacin (Levaquin), and others;

some nonsteroidal anti-inflammatory drugs (NSAIDs);

aspirin or other salicylates (including Pepto-Bismol);

a blood thinner (warfarin, Coumadin and others);

a monoamine oxidase inhibitor (MAOI);

sulfa drugs (Bactrim, Gantanol, Septra, and others); or

other oral diabetes medications, especially acarbose (Precose), metformin (Glucophage), miglitol (Glyset), pioglitazone (Actos), or rosiglitazone (Avandia).

You may be more likely to have hyperglycemia (high blood sugar) if you take glimepiride with:

isoniazid;

diuretics (water pills);

steroids (prednisone and others);

niacin (Advicor, Niaspan, Niacor, Niaspan, Simcor, Slo-Niacin, and others);

phenothiazines (Compazine and others);

thyroid medicine (Synthroid and others);

birth control pills and other hormones;

seizure medicines (Dilantin and others);

diet pills; and

medicines to treat asthma, colds or allergies.

These lists are not complete and there are many other medicines that can increase or decrease the effects of glimepiride on lowering your blood sugar. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

More glimepiride resources

Glimepiride Side Effects (in more detail)
Glimepiride Dosage
Glimepiride Use in Pregnancy & Breastfeeding
Drug Images
Glimepiride Drug Interactions
Glimepiride Support Group
11 Reviews for Glimepiride - Add your own review/rating

glimepiride Advanced Consumer (Micromedex) - Includes Dosage Information

Glimepiride Prescribing Information (FDA)

Glimepiride Professional Patient Advice (Wolters Kluwer)

Glimepiride Monograph (AHFS DI)

Glimepiride MedFacts Consumer Leaflet (Wolters Kluwer)

Amaryl Prescribing Information (FDA)

Amaryl Consumer Overview

Compare glimepiride with other medications

Diabetes, Type 2

Where can I get more information?

Your pharmacist can provide more information about glimepiride.

See also: glimepiride side effects (in more detail)

Fiorance

Fiorance may be available in the countries listed below.

Ingredient matches for Fiorance

Ipriflavone

Ipriflavone is reported as an ingredient of Fiorance in the following countries:

Japan

International Drug Name Search

Alfentanil-hameln

Alfentanil-hameln may be available in the countries listed below.

Ingredient matches for Alfentanil-hameln

Alfentanil

Alfentanil hydrochloride (anhydrous) (a derivative of Alfentanil) is reported as an ingredient of Alfentanil-hameln in the following countries:

Germany

International Drug Name Search

Monday, October 24, 2016

garlic

Generic Name: garlic (GAR lick)

Brand names: Garlic, Garlic Oil

What is garlic?

The use of garlic in cultural and traditional settings may differ from concepts accepted by current Western medicine. When considering the use of herbal supplements, consultation with a primary health care professional is advisable. Additionally, consultation with a practitioner trained in the uses of herbal/health supplements may be beneficial, and coordination of treatment among all health care providers involved may be advantageous.

Garlic is also known as rocambole, ajo, allium, stinking rose, rustic treacle, nectar of the gods, camphor of the poor, poor man's treacle, and clove garlic.

Garlic is a commonly used flavoring agent and food product. Garlic is also available as an herbal supplement. The information contained in this leaflet refers to the use of garlic as an herbal supplement. When used as a food product, the benefits and potential side effects of garlic may be less pronounced than when it is used as an herbal supplement.

Garlic has been used orally as an antioxidant; to reduce cholesterol and triglycerides; to reduce hardening of the arteries and blood clotting; to reduce blood pressure; to prevent cancer; to protect the liver; as an antibiotic, antiviral, and antifungal; to increase the effects of the immune system; to reduce blood sugar levels; and to reduce menstrual pain. Garlic has also been used topically (on the skin) to treat corns, warts, calluses, ear infections, muscle pain, nerve pain, arthritis, and sciatica.

Garlic has not been evaluated by the FDA for safety, effectiveness, or purity. All potential risks and/or advantages of garlic may not be known. Additionally, there are no regulated manufacturing standards in place for these compounds. There have been instances where herbal/health supplements have been sold which were contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Garlic may also have uses other than those listed in this product guide.

What is the most important information I should know about garlic?

Do not take garlic without first talking to your doctor if you have a bleeding or blood clotting disorder or diabetes, or if you are taking any medicines to prevent or treat a blood clotting disorder or diabetes. Garlic has been reported to affect blood clotting and blood sugar levels.

What should I discuss with my healthcare provider before taking garlic?

Also, talk to your doctor before taking garlic if you have any other medical conditions, if you take medicines or herbal/health supplements other than those previously listed, or if you suffer from allergies (especially to plants). Garlic may not be recommended in some situations.

Do not take garlic supplements without first talking to your doctor if you are pregnant or planning a pregnancy. It is not known whether garlic will harm an unborn baby. The amount of garlic customarily used in foods is not reported to be problematic. Do not take garlic without first talking to your doctor if you are breast-feeding a baby. It is also not known whether garlic will harm a nursing infant. The amount of garlic customarily used in foods is not reported to be problematic. There is no information available regarding the use of garlic supplements by children. Do not give any herbal/health supplement to a child without first talking to the child's doctor.

How should I take garlic?

If you choose to take garlic, use it as directed on the package or as directed by your doctor, pharmacist, or other health care provider.

Standardized extracts, tinctures, and solid formulations of herbal/health supplements may provide a more reliable dose of the product.

Garlic is available in the clove form, in capsules, as tablets and as an oil. Other formulations may also be available.

Generally, the preferred forms of garlic for oral use are enteric-coated odorless garlic and fresh garlic which has been pressed or crushed for 10 to 15 minutes before using.

Do not use different formulations (e.g., tablets, topical formulations, teas, tinctures, and others) of garlic at the same time, unless specifically directed to do so by a health care professional. Using different formulations together increases the risk of an overdose of garlic.

Store garlic as directed on the package. In general, garlic should be protected from light and moisture.

What happens if I miss a dose?

No information is available regarding a missed dose of garlic. Consult your doctor, pharmacist, or health care provider if you require further information.

What happens if I overdose?

An overdose of garlic is unlikely to threaten life. Consult a doctor, hospital, or poison control center if you require assistance.

Symptoms of a garlic overdose have not been reported.

What should I avoid while taking garlic?

There are no known restrictions on food, beverages, or activity while taking garlic, unless otherwise directed by your health care provider.

Garlic side effects

Although uncommon, allergic reactions to garlic have been reported. Stop taking garlic and seek emergency medical attention if you experience symptoms of a serious allergic reaction including difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives.

Other less serious side effects have also been reported. Talk to your doctor or pharmacist if you experience

burning of the mouth, throat, and stomach;

nausea or vomiting;

diarrhea;

sweating;

lightheadedness; and

eczema or a rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect garlic?

Do not take garlic without first talking to your doctor if you are taking any of the following medicines:

a medicine to control blood sugar levels such as insulin, glipizide (Glucotrol), glyburide (Glynase, Diabeta, Micronase), chlorpropamide (Diabinese), tolbutamide (Orinase), tolazamide (Tolinase), pioglitazone (Actos), rosiglitazone (Avandia), repaglinide (Prandin), metformin (Glucophage), and others;

a nonsteroidal anti-inflammatory drug (NSAID) including ibuprofen (Advil, Motrin, Nuprin, others), naproxen (Aleve, Naprosyn, Naprelan, Anaprox, others), ketoprofen (Orudis KT, Orudis), indomethacin (Indocin), etodolac (Lodine), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), tolmetin (Tolectin), and others;

a protease inhibitor such as amprenavir (Agenerase), indinavir (Crixivan), saquinavir (Invirase, Fortovase), lopinavir-ritonavir (Kaletra), ritonavir (Norvir), or nelfinavir (Viracept);

ardeparin (Normiflo), dalteparin (Fragmin), danaparoid (Orgaran), enoxaparin (Lovenox), tinzaparin (Innohep);

warfarin (Coumadin);

aspirin; or

heparin.

You may not be able to take garlic, or you may require a dosage adjustment or special monitoring while taking garlic if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with garlic or affect your condition. Talk to your doctor, pharmacist, or health care provider before taking any prescription or over-the-counter medicines or other herbal/health supplements.

More garlic resources

Garlic Side Effects (in more detail)
Garlic Use in Pregnancy & Breastfeeding
Garlic Drug Interactions
Garlic Support Group
0 Reviews for Garlic - Add your own review/rating

Garlic Natural MedFacts for Professionals (Wolters Kluwer)

Garlic Natural MedFacts for Consumers (Wolters Kluwer)

Garlic MedFacts Consumer Leaflet (Wolters Kluwer)

Compare garlic with other medications

Bacterial Infection
Coronary Artery Disease
Herbal Supplementation
High Cholesterol
Human Papilloma Virus
Neuralgia
Otitis Externa
Premenstrual Dysphoric Disorder
Rheumatoid Arthritis
Sciatica

Where can I get more information?

Your doctor, pharmacist, or health care provider may have more information about garlic.

See also: garlic side effects (in more detail)

Friday, October 21, 2016

Mydriacyl

In some countries, this medicine may only be approved for veterinary use.

In the US, Mydriacyl (tropicamide ophthalmic) is a member of the drug class mydriatics and is used to treat Pupillary Dilation and Refraction - Assessment.

US matches:

Mydriacyl

Mydriacyl Ophthalmic

UK matches:

Mydriacyl 0.5% (SPC)
Mydriacyl 1% (SPC)

Ingredient matches for Mydriacyl

Tropicamide

Tropicamide is reported as an ingredient of Mydriacyl in the following countries:

Australia

Bangladesh

Belgium

Botswana

Brazil

Canada

Chile

Denmark

Eritrea

Estonia

Ethiopia

Ghana

Hong Kong

Iceland

Ireland

Kenya

Latvia

Lithuania

Malawi

Namibia

New Zealand

Nigeria

Oman

Peru

Romania

Singapore

Slovenia

South Africa

Sri Lanka

Sweden

Taiwan

Tanzania

Uganda

United Kingdom

United States

Zambia

Zimbabwe

International Drug Name Search

Glossary

SPC

Summary of Product Characteristics (UK)

Click for further information on drug naming conventions and International Nonproprietary Names.

C-Fenac

C-Fenac may be available in the countries listed below.

Ingredient matches for C-Fenac

Diclofenac

Diclofenac sodium salt (a derivative of Diclofenac) is reported as an ingredient of C-Fenac in the following countries:

Bangladesh

International Drug Name Search

Prostin 15M

Prostin 15M may be available in the countries listed below.

Ingredient matches for Prostin 15M

Carboprost

Carboprost is reported as an ingredient of Prostin 15M in the following countries:

Luxembourg

Serbia

Carboprost tromethamine (a derivative of Carboprost) is reported as an ingredient of Prostin 15M in the following countries:

Belgium

Bosnia & Herzegowina

Croatia (Hrvatska)

Czech Republic

Netherlands

New Zealand

Serbia

Slovakia

International Drug Name Search

Thursday, October 20, 2016

Trochain

Trochain may be available in the countries listed below.

Ingredient matches for Trochain

Benzocaine

Benzocaine is reported as an ingredient of Trochain in the following countries:

South Africa

Cetrimide

Cetrimide is reported as an ingredient of Trochain in the following countries:

South Africa

International Drug Name Search

Garamycin

Generic Name: gentamicin (gen tah MY sin)

Brand Names: Garamycin

What is Garamycin (gentamicin)?

Gentamicin is an antibiotic. It fights bacteria in the body.

Gentamicin is used to treat severe or serious bacterial infections.

Gentamicin may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Garamycin (gentamicin)?

If you are injecting gentamicin at home, your healthcare provider will give you detailed instructions on how and where to inject the medication. If you do not understand these directions, do not attempt to inject the medication. Contact your healthcare provider for further instructions.

Gentamicin may cause damage to the kidneys and/or nerves. Kidney function and drug levels in the blood may be monitored with blood tests during treatment. Tell your doctor if you experience hearing loss, dizziness, numbness, skin tingling, muscle twitching, or seizures which may be signs of nerve damage.

What should I discuss with my healthcare provider before using Garamycin (gentamicin)?

Do not use gentamicin without first talking to your doctor if you have

sulfite sensitivity;

kidney disease;

hearing loss or loss of balance due to ear problems;

Parkinson's disease; or

a neuromuscular disorder such as myasthenia gravis.

You may not be able to use gentamicin, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Do not use gentamicin without first talking to your doctor if you are pregnant or could become pregnant during treatment. Do not use gentamicin without first talking to your doctor if you are breast-feeding a baby.

How should I take Garamycin (gentamicin)?

Do not use any gentamicin that is discolored, has particles in it, or looks different from your previous doses. Throw away any unused gentamicin after the amount of time determined by your pharmacist or doctor.

Adequate hydration is important during treatment with gentamicin. Fluids may be administered intravenously during treatment.

It is important that the medication be given on a regular schedule and for the entire amount of time prescribed by your doctor.

Dispose of used needles and syringes in a puncture resistant container out of the reach of children.

Your healthcare provider will store gentamicin as directed by the manufacturer or give you detailed storage instructions if you are storing the medication at home.

What happens if I miss a dose?

Contact your doctor if a dose is missed.

What happens if I overdose?

Contact your doctor or seek emergency medical attention if an overdose is suspected. An overdose of the medication may result in damage to the kidneys or hearing loss, dizziness, numbness, skin tingling, muscle twitching, or seizures (which may be signs of nerve damage).

What should I avoid while taking Garamycin (gentamicin)?

There are no restrictions on food, beverages, or activity while taking gentamicin unless otherwise directed by your doctor.

Garamycin (gentamicin) side effects

If you experience any of the following serious side effects, stop taking gentamicin and seek emergency medical attention:

an allergic reaction (shortness of breath; closing of the throat; hives; swelling of the lips, face, or tongue; rash; or fainting);

little or no urine;

decreased hearing or ringing in the ears;

dizziness, clumsiness, or unsteadiness;

numbness, skin tingling, muscle twitching, or seizures; or

severe watery diarrhea and abdominal cramps.

Other, less serious side effects may be more likely to occur. Continue to take gentamicin and talk to your doctor if you experience

increased thirst;

loss of appetite;

nausea or vomiting;

a rash.

What other drugs will affect Garamycin (gentamicin)?

Other drugs, especially those that affect the kidneys, can interact with gentamicin resulting in dangerous side effects and/or decreased effectiveness. Do not take any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products, without first talking to your doctor during treatment with gentamicin.

More Garamycin resources

Garamycin Side Effects (in more detail)
Garamycin Use in Pregnancy & Breastfeeding
Garamycin Drug Interactions
Garamycin Support Group
0 Reviews for Garamycin - Add your own review/rating

Garamycin Solution MedFacts Consumer Leaflet (Wolters Kluwer)

Garamycin Injection Advanced Consumer (Micromedex) - Includes Dosage Information

Gentamicin Cream MedFacts Consumer Leaflet (Wolters Kluwer)

Gentamicin Professional Patient Advice (Wolters Kluwer)

Gentamicin Sulfate Monograph (AHFS DI)

Compare Garamycin with other medications

Bacteremia
Bacterial Endocarditis Prevention
Bacterial Infection
Bone infection
Brucellosis
Burns, External
Cystic Fibrosis
Endocarditis
Endometritis
Febrile Neutropenia
Intraabdominal Infection
Kidney Infections
Meningitis
Pelvic Inflammatory Disease
Peritonitis
Plague
Pneumonia
Rabbit Fever
Skin Infection
Surgical Prophylaxis

Where can I get more information?

Your pharmacist has additional information about gentamicin written for health professionals that you may read.

See also: Garamycin side effects (in more detail)

Gas-X Extra Strength

Generic Name: simethicone (sye METH i cone)

Brand Names: Alka-Seltzer Anti-Gas, Equalize Gas Relief Drops, Gas Aide, Gas Free Extra Strength, Gas-X, Gas-X Extra Strength, Gas-X Infant Drops, Gas-X Maximum Strength, Gas-X Thin Strips Cinnamon, Gas-X Thin Strips Peppermint, Gas-X Tongue Twisters Thin Strips Children's, Gas-X Ultra Softgels, Genasyme, Infantaire Gas Relief, Little Tummys, Maalox Anti-Gas, Maalox Anti-Gas Extra Strength, Mi-Acid Gas Relief, Mylanta Gas, Mylanta Gas Maximum Strength, Mylicon, Mytab Gas, Phazyme, Phazyme Maximum Strength, Phazyme Ultra, Phazyme-125, Phazyme-95

What is Gas-X Extra Strength (simethicone)?

Simethicone allows gas bubbles in the stomach and intestines to come together more easily, which allows for easier passage of gas.

Simethicone is used to relieve painful pressure caused by excess gas in the stomach and intestines. Simethicone is for use in babies, children, and adults.

Simethicone may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Gas-X Extra Strength (simethicone)?

Never use more than the recommended dose of simethicone.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you are allergic to any drugs, or if you have any type of serious illness (especially one that affects your stomach or intestines).

Simethicone works best if you take it after meals and at bedtime.

Simethicone may be only part of a complete program of treatment that may also include a special diet or increased exercise. It is very important to follow the diet and exercise plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you must avoid to help control your condition.

There may be other drugs that can interact with simethicone. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

What should I discuss with my healthcare provider before taking Gas-X Extra Strength (simethicone)?

You should not use this medication if you are allergic to simethicone.

Simethicone is not expected to harm an unborn baby. It is not known whether simethicone passes into breast milk or if it could harm a nursing baby. Do not use this medication without medical advice if you are breast-feeding a baby.

The liquid form may contain phenylalanine. Talk to your doctor before using this form of simethicone if you have phenylketonuria (PKU).

How should I take Gas-X Extra Strength (simethicone)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Do not take more of this medication than is directed.

Simethicone works best if you take it after meals and at bedtime.

The simethicone chewable tablet must be chewed before swallowing.

Measure liquid medicine with a special dose measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose measuring device, ask your pharmacist for one. Clean the medicine dropper after each use. Allow it to air dry.

Simethicone liquid drops can be mixed with water, baby formula, or other liquids to make swallowing easier for an infant or child.

Children should never be given more than the recommended dose of simethicone. Call your doctor if the child's gas symptoms do not improve after treatment with simethicone.

Store at room temperature away from moisture, heat, and light. Do not allow the liquid form of this medicine to freeze.

What happens if I miss a dose?

Since simethicone is used on an as needed basis, you are not likely to miss a dose. Do not use more of this medication than is directed.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Gas-X Extra Strength (simethicone)?

Ask a doctor or pharmacist before using any other stomach medicine or antacid. Simethicone is contained in many combination medicines. Taking certain products together can cause you to get too much simethicone.

Gas-X Extra Strength (simethicone) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Gas-X Extra Strength (simethicone)?

More Gas-X Extra Strength resources

Gas-X Extra Strength Side Effects (in more detail)
Gas-X Extra Strength Use in Pregnancy & Breastfeeding
Gas-X Extra Strength Support Group
2 Reviews for Gas-X Extra Strength - Add your own review/rating

Gas-X Extra Strength MedFacts Consumer Leaflet (Wolters Kluwer)

Simethicone Professional Patient Advice (Wolters Kluwer)

Simethicone Monograph (AHFS DI)

Alka-Seltzer Anti-Gas Advanced Consumer (Micromedex) - Includes Dosage Information

Bicarsim MedFacts Consumer Leaflet (Wolters Kluwer)

Gas-X Chewable Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

Gas-X Infant Drops Liquid Drops MedFacts Consumer Leaflet (Wolters Kluwer)

Genasyme Suspension MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Gas-X Extra Strength with other medications

Where can I get more information?

Your pharmacist can provide more information about simethicone.

See also: Gas-X Extra Strength side effects (in more detail)

Glucophage XR Extended-Release Tablets

Pronunciation: met-FOR-min
Generic Name: Metformin
Brand Name: Examples include Fortomet and Glucophage XR

Glucophage XR Extended-Release Tablets may rarely cause a serious and sometimes fatal condition called lactic acidosis. Most of these cases have occurred in diabetic patients who also have certain kidney problems. The risk of lactic acidosis may be greater if you have liver problems, kidney problems, or heart failure. The risk may also be greater in patients who are elderly or drink alcohol. Lab tests, including kidney function, may be performed while you take Glucophage XR Extended-Release Tablets.

Do not begin to take Glucophage XR Extended-Release Tablets if you are 80 years or older unless lab tests show that you do not have decreased kidney function. Do not take it if you have a severe infection, have low blood oxygen levels, or are dehydrated. Tell your doctor you take Glucophage XR Extended-Release Tablets before you have any surgery or lab procedures.

Contact your doctor right away if you notice symptoms such as fast or difficult breathing; muscle pain or tenderness; slow or irregular heartbeat; unusual drowsiness, dizziness, or light-headedness; unusual stomach discomfort; or unusual weakness or tiredness. Contact your doctor right away if you start to feel unusually cold or if you have a general feeling of being unwell.

Glucophage XR Extended-Release Tablets are used for:

Treating type 2 diabetes. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines.

Glucophage XR Extended-Release Tablets are a biguanide antidiabetic. It works by decreasing the amount of sugar that the liver produces and the intestines absorb. It also helps to make your body more sensitive to the insulin that you naturally produce.

Do NOT use Glucophage XR Extended-Release Tablets if:

you are allergic to any ingredient in Glucophage XR Extended-Release Tablets

you have a severe infection, low blood oxygen levels, kidney or liver problems, high blood ketone or acid levels (eg, diabetic ketoacidosis), or dehydration

you have had a stroke or a recent heart attack, or you are in shock

you are 80 years or older and have not had a kidney function test

you will be having surgery or certain lab procedures

Contact your doctor or health care provider right away if any of these apply to you.

Before using Glucophage XR Extended-Release Tablets:

Some medical conditions may interact with Glucophage XR Extended-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have heart failure, especially heart failure that is treated by medicine

if you have a history of heart problems, lung or breathing problems, thyroid problems, stomach or bowel problems (eg, paralysis, blockage), adrenal or pituitary problems, or lactic acidosis

if you have vomiting, diarrhea, poor health or nutrition, low blood calcium or vitamin B₁₂ levels, or anemia, or if you are dehydrated

if you have an infection, fever, recent injury, or moderate to severe burns

if you drink alcohol or have a history of alcohol abuse

if you will be having surgery or certain lab procedures

if you are taking a beta-blocker (eg, propranolol)

Some MEDICINES MAY INTERACT with Glucophage XR Extended-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

Calcium channel blockers (eg, nifedipine), corticosteroids (eg, prednisone), diuretics (eg, furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (eg, birth control pills), insulin, isoniazid, nicotinic acid, phenothiazine (eg, chlorpromazine), phenytoin, sulfonylureas (eg, glipizide), sympathomimetics (eg, albuterol, pseudoephedrine), or thyroid hormones (eg, levothyroxine) because the risk of high or low blood sugar may be increased

Amiloride, cimetidine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin, or medicines that may harm the kidney (eg, aminoglycoside antibiotics [eg, gentamicin], amphotericin B, tacrolimus) because they may increase the risk of Glucophage XR Extended-Release Tablets's side effects. Ask you doctor if you are unsure if any of your medicines might harm the kidney

This may not be a complete list of all interactions that may occur. Ask your health care provider if Glucophage XR Extended-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Glucophage XR Extended-Release Tablets:

Use Glucophage XR Extended-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

An extra patient leaflet is available with Glucophage XR Extended-Release Tablets. Talk to your pharmacist if you have questions about this information.

Take Glucophage XR Extended-Release Tablets by mouth with the evening meal unless your doctor tells you otherwise.

Swallow Glucophage XR Extended-Release Tablets whole. Do not break, crush, or chew before swallowing.

Take Glucophage XR Extended-Release Tablets on a regular schedule to get the most benefit from it. Taking Glucophage XR Extended-Release Tablets at the same time each day will help you remember to take it.

Continue to take Glucophage XR Extended-Release Tablets even if you feel well. Do not miss any doses.

If you miss a dose of Glucophage XR Extended-Release Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Glucophage XR Extended-Release Tablets.

Important safety information:

Glucophage XR Extended-Release Tablets may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Glucophage XR Extended-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Follow the diet and exercise program given to you by your health care provider.

Do not drink large amounts of alcohol while you take Glucophage XR Extended-Release Tablets. Talk to your doctor or health care provider before you drink alcohol while you take Glucophage XR Extended-Release Tablets.

Tell your doctor or dentist that you take Glucophage XR Extended-Release Tablets before you receive any medical or dental care, emergency care, or surgery.

Be careful not to become dehydrated, especially during hot weather or while you are being active. Dehydration may increase the risk of Glucophage XR Extended-Release Tablets's side effects.

If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.

You may notice undissolved parts of Glucophage XR Extended-Release Tablets in your stool. This is normal and not a cause for concern.

Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher or lower than they should be and you take Glucophage XR Extended-Release Tablets exactly as prescribed, tell your doctor.

Glucophage XR Extended-Release Tablets does not usually cause low blood sugar. Low blood sugar may be more likely to occur if you skip a meal, exercise heavily, or drink alcohol. It may also be more likely if you take Glucophage XR Extended-Release Tablets along with certain medicines for diabetes (eg, sulfonylureas, insulin). Tell your doctor right away if you experience symptoms of low blood sugar (eg, fast heartbeat, headache, chills, sweating, tremors, increased hunger, vision changes, nervousness, weakness, dizziness, drowsiness, fainting).

It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.

Fever, infection, injury, or surgery may increase your risk of high or low blood sugar levels. If any of these occur, check your blood sugar level closely and tell your doctor right away.

Glucophage XR Extended-Release Tablets may commonly cause stomach upset, indigestion, nausea, vomiting, or diarrhea at the beginning of treatment. If you develop unusual or unexpected stomach problems, or if you develop stomach problems later during treatment, contact your doctor at once. This may be a sign of lactic acidosis.

Lab tests, including kidney function, fasting blood glucose, hemoglobin A_1c, and complete blood cell counts, may be performed while you take Glucophage XR Extended-Release Tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Glucophage XR Extended-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects. Low blood sugar levels may also be more difficult to recognize in the elderly.

Glucophage XR Extended-Release Tablets should not be used in CHILDREN younger than 17 years; safety and effectiveness in these children have not been confirmed.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Glucophage XR Extended-Release Tablets while you are pregnant. It is not known if Glucophage XR Extended-Release Tablets are found in breast milk. Do not breast-feed while taking Glucophage XR Extended-Release Tablets.

When used for long periods of time, Glucophage XR Extended-Release Tablets may not work as well. If your blood sugar has been under control and then becomes hard to manage, contact your doctor. Do not change the dose of your medicine without checking with your doctor.

Possible side effects of Glucophage XR Extended-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; gas; headache; indigestion; nausea; stomach pain or upset; temporary metallic taste; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain or discomfort; dizziness or light-headedness; fast or difficult breathing; feeling of being unusually cold; fever, chills, or persistent sore throat; general feeling of being unwell; muscle pain or weakness; slow or irregular heartbeat; unusual drowsiness; unusual or persistent stomach pain or discomfort; unusual tiredness or weakness.

See also: Glucophage XR side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include dizziness or light-headedness; fast or difficult breathing; feeling of being unusually cold; general feeling of being unwell; muscle pain or tenderness; slow or irregular heartbeat; unusual drowsiness; unusual stomach discomfort; unusual weakness or tiredness.

Proper storage of Glucophage XR Extended-Release Tablets:

Store Glucophage XR Extended-Release Tablets at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Glucophage XR Extended-Release Tablets out of the reach of children and away from pets.

General information:

If you have any questions about Glucophage XR Extended-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.

Glucophage XR Extended-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Glucophage XR Extended-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

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